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Bendroflumethiazide, often referred to simply as bendroflumethiazide or bendrofluthiazide, is a thiazide diuretic commonly used in the treatment of hypertension (high blood pressure) and edema associated with heart failure and other conditions. It works by inhibiting sodium reabsorption at the distal convoluted tubule in the kidneys, which leads to increased excretion
of sodium and water, thereby reducing blood volume and lowering blood pressure.
Clinical studies have demonstrated that bendroflumethiazide effectively reduces both systolic and diastolic blood pressure. It is often well-tolerated and can be particularly effective when used in combination with other antihypertensive agents, such as ACE inhibitors or calcium channel blockers, enhancing overall blood pressure control while minimizing the risk of heart-related complications.
In addition to its antihypertensive effects, bendroflumethiazide is useful in managing fluid retention in patients with conditions such as heart failure or certain liver disorders. By promoting diuresis, it helps alleviate symptoms associated with fluid overload, such as swelling and shortness of breath.
While generally safe, bendroflumethiazide may cause side effects such as electrolyte imbalances (notably hypokalemia, or low potassium levels), dizziness, increased urination, and elevated blood glucose levels. Regular monitoring of renal function, electrolyte levels, and blood pressure is essential, especially during initial treatment and dose adjustments.
Overall, bendroflumethiazide is an effective thiazide diuretic in the management of hypertension and fluid retention, leading to improved patient outcomes and quality of life. Patients should maintain regular follow-up appointments to monitor treatment efficacy and manage any potential side effects.
Bendroflumethiazide, commonly referred to as bendrofluazide, is a thiazide diuretic primarily used for the treatment of hypertension and fluid retention (edema) associated with heart failure and other conditions. The typical starting dosage for adults is usually 2.5 mg to 5 mg taken orally once daily, based on the severity of the condition being treated. Depending on the
patient's response and clinical circumstances, the dose may be adjusted, with some patients requiring doses up to 10 mg per day.
Bendroflumethiazide can be taken with or without food, but taking it in the morning is often recommended to avoid nocturia (excessive urination at night) and to fit the diuretic's diuretic effect within the daytime hours. Patients should swallow the tablets whole with a glass of water and should not crush or chew them.
If you miss a dose of bendroflumethiazide and remember it within a few hours of the scheduled time, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed dose and return to your normal dosing schedule; do not take two doses at the same time to make up for a missed one.
To maintain the best therapeutic outcome, it is essential to follow your healthcare provider's instructions regarding dosage and to monitor for potential side effects, particularly electrolyte imbalances. Regular follow-up appointments are important for assessing blood pressure and renal function, as well as managing any complications that may arise during treatment. If you have questions about how to take bendroflumethiazide or concerns about missed doses, consult your healthcare provider for personalized guidance.
Always use this medication exactly as your clinician has told you. Check with our clinical team or your GP or pharmacist if you are not sure.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Here’s a detailed breakdown of the side effects associated with bendroflumethiazide (commonly referred to as bendrofluazide), categorized into common, less common, rare side
effects, and important considerations:
1. Electrolyte Imbalances: Bendrofluazide can lead to imbalances, particularly hypokalemia (low potassium levels), which may cause weakness, muscle cramps, or arrhythmias.
2. Increased Urination: As a diuretic, bendrofluazide promotes increased urine output, which is expected but may lead to inconvenience for some patients.
3. Dizziness: Patients may experience dizziness or lightheadedness, especially when standing up quickly (orthostatic hypotension).
4. Fatigue: Some individuals report feelings of tiredness or lethargy while on this medication.
5. Nausea: Gastrointestinal disturbances, including nausea or upset stomach, may occur.
1. Hypomagnesemia: Low levels of magnesium can occur, potentially leading to symptoms like muscle spasms or irregular heart rhythms.
2. Gout: Bendrofluazide can precipitate or worsen gout by increasing uric acid levels.
3. Skin Reactions: Rash, itching, or sensitivity to sunlight (photosensitivity) may occur.
4. Impotence: Some male patients may experience erectile dysfunction or reduced libido.
1. Pancreatitis: In rare cases, patients may develop inflammation of the pancreas.
2. Hepatic Effects: Elevations in liver enzymes may indicate potential liver dysfunction, requiring monitoring.
3. Thrombocytopenia: A decrease in platelet count may occur, which can increase the risk of bleeding or bruising.
1. First-Dose Effect: Patients may experience marked hypotension when taking the first dose of doxazosin. Therefore, it is often recommended to start with a low dose, preferably at bedtime, to minimize this risk.
2. Monitoring: Regular monitoring of blood pressure is essential, especially during the initiation of therapy or after any dosage adjustments.
3. Drug Interactions: Patients should inform their healthcare provider about all medications they are taking, as doxazosin can interact with other antihypertensives or medications affecting blood pressure.
4. Caution in Patients with a History of Prostate Cancer: Since doxazosin is used to relieve symptoms of benign prostatic hyperplasia (BPH), caution is advised in patients with prostate cancer, as its effects and safety profile require careful evaluation.
For full information on side effects and correct use, see the patient information leaflet. If any side effects concern you, or you are experiencing any of the side effects mentioned in the patient information leaflet whilst taking this medication, please contact our clinical team or speak to your GP.
1. Electrolyte Imbalances: Bendrofluazide can cause imbalances, particularly hypokalemia (low potassium levels), which may lead to muscle weakness, cramps, or rhythm disturbances. Regular monitoring of electrolyte levels, especially potassium, is essential.
2. Renal Impairment: Caution should be exercised in patients with pre-existing renal impairment, as thiazide diuretics like bendrofluazide can further decrease renal function. Dosage adjustments and careful monitoring may be required.
3. Diabetes: Bendrofluazide can cause increases in blood glucose levels, potentially complicating the management of diabetes. Patients with diabetes should have their blood glucose monitored regularly during treatment.
4. Gout: The use of bendrofluazide can increase uric acid levels and potentially precipitate or exacerbate gout attacks. Patients with a history of gout should be monitored closely.
5. Liver Impairment: Caution is advised in patients with liver impairment, as the risk of fluid and electrolyte imbalance can be increased, leading to further complications.
6. Elderly Population: Older adults may have an increased sensitivity to diuretics and may require careful monitoring and potential dosage adjustments.
1. Hypotension: Bendrofluazide can lead to significant reductions in blood pressure, particularly when initiating therapy or increasing the dose. Patients should be monitored for symptoms of hypotension, such as dizziness or fainting.
2. Drug Interactions: Bendrofluazide may interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), which can reduce its antihypertensive effect, and lithium, which may lead to toxicity if used concurrently. Patients should disclose all medications to their healthcare provider.
3. Withdrawal: Abrupt discontinuation of bendrofluazide can lead to a rebound increase in blood pressure, so any changes in therapy should be directed by a healthcare provider.
4. Monitoring: Regular follow-up appointments are crucial for monitoring blood pressure, renal function, and electrolyte levels during treatment to prevent complications.
Get emergency medical help if you have signs of an allergic reaction to this medication. These include:
It is important that you let us know which prescription, over-the-counter medicines and recreational drugs you are currently taking. You must also tell us about any other medical conditions that you currently have (or had in the past). This will help us ensure the prescribed medication is safe and appropriate for you to take.
For full information on warnings, medication interactions and contraindications, refer to the Patient Information Leaflet. Please read all packaging and the Patient Information Leaflet before taking any new medicine and inform our clinical team or your GP of medicines you are taking or intend to take.
