Elleste Duet tablets are a combined hormone replacement therapy (HRT) specifically formulated for women experiencing menopausal symptoms. Each tablet contains two types of hormones: estradiol, a form of estrogen, and norethisterone, a synthetic progestogen. This combination therapy is designed for women who have not undergone a hysterectomy, as the progestogen component helps protect the endometrium (lining of the uterus) from hyperplasia, which can occur with estrogen-only therapy.
Elleste Duet is indicated for the relief of moderate to severe menopausal symptoms, including hot flashes, night sweats, and vaginal dryness. It can also play a role in preventing osteoporosis in postmenopausal women who are at risk due to estrogen deficiency.
Clinical studies have demonstrated that Elleste Duet effectively reduces both the frequency and severity of menopausal symptoms. Women using this HRT often report significant improvements in quality of life, with a marked decline in hot flashes and other vasomotor symptoms. Additionally, the progestogen component helps to mitigate the risk of endometrial cancer, providing safe and comprehensive hormonal support.
While Elleste Duet is generally well tolerated, potential side effects can occur. Common side effects may include nausea, headache, breast tenderness, and mood changes. Serious side effects, though rare, can include thromboembolic events, such as deep vein thrombosis or pulmonary embolism, particularly in women with additional risk factors.
Regular follow-up appointments with healthcare providers are essential for monitoring treatment efficacy and managing any possible side effects. Patients should be counseled on the risks and benefits of combined HRT, particularly regarding contraindications like a history of hormone-sensitive cancers, liver disease, or active thromboembolic disorders.
In summary, Elleste Duet tablets offer an effective solution for managing menopausal symptoms through a combination of estrogen and progestogen, playing a vital role in improving women's health and quality of life during the menopause transition. Consistent monitoring and open communication with healthcare providers are crucial for optimizing treatment outcomes and ensuring safety.
Elleste Duet tablets are used for hormone replacement therapy (HRT) to manage menopausal symptoms in women. The typical regimen consists of two types of tablets: one containing estradiol (the estrogen component) and another containing both estradiol and norethisterone (the progestogen component). For those starting treatment, the usual dosage involves taking one estrogen-only tablet for the first 14 days, followed by one combined tablet for the next 14 days, forming a complete cycle of 28 days.
To take Elleste Duet, swallow the tablet whole with a glass of water, and it can be taken with or without food, which allows for flexibility regarding meal times. It is important to take your tablet at the same time each day to maintain consistent hormone levels in your system.
If you forget to take your Elleste Duet tablet and remember it within 12 hours, take it as soon as you remember. However, if it is almost time for your next scheduled tablet, skip the missed dose and continue with your regular dosing schedule; do not take two tablets together to make up for the missed dose.
Regular follow-up appointments with your healthcare provider are essential to evaluate your treatment effectiveness and manage any side effects you may experience. If you have questions about how to take Elleste Duet or concerns regarding missed doses, consult your healthcare provider for personalized advice.
Always use this medication exactly as your clinician has told you. Check with our clinical team or your GP or pharmacist if you are not sure.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Elleste Duet is a hormone replacement therapy (HRT) medication that contains estradiol, a form of estrogen. It is primarily used to alleviate symptoms of menopause in women who have had their uterus removed (hysterectomy) and need estrogen to help manage symptoms such as hot flashes, night sweats, and vaginal dryness.
Common Side Effects
1. Skin Reactions Irritation, redness, or rash at the application site.
2. Breast Changes Tenderness, swelling, or changes in breast tissue.
3. Headaches Including migraines or tension-type headaches.
4. Nausea Gastrointestinal upset may occur.
5. Weight Changes Some women may experience weight gain or loss.
Less Common Side Effects
1. Mood Changes Anxiety, depression, or mood swings.
2. Gastrointestinal Issues Diarrhea or stomach cramps.
3. Fluid Retention Swelling in the ankles or hands.
Rare but Serious Side Effects
1. Thromboembolic Events Increased risk of blood clots, deep vein thrombosis, pulmonary embolism, and stroke.
2. Cardiovascular Issues Potential increase in blood pressure or heart attack risk.
3. Endometrial Hyperplasia Overgrowth of the uterine lining, which can lead to abnormal bleeding.
4. Liver Problems Changes in liver function or liver disease.
For full information on side effects and correct use, see the patient information leaflet. If any side effects concern you, or you are experiencing any of the side effects mentioned in the patient information leaflet whilst taking this medication, please contact our clinical team or speak to your GP.
Elleste Duet is a hormone replacement therapy (HRT) medication that contains a combination of estradiol (an estrogen) and norethisterone (a progestogen), typically used to relieve menopausal symptoms in women who still have their uterus. Here are the detailed cautions and warnings associated with Elleste Duet:
1. Dosage and Administration: Adhere strictly to the prescribed regimen. Overuse or incorrect application of the patches can lead to elevated estradiol levels, resulting in potential side effects and complications.
2. Cardiovascular Risks: Elleste Duet can increase the risk of thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Women with a history of cardiovascular disease, smoking, obesity, or prolonged immobility are at higher risk.
3. Breast Cancer Risk: Prolonged use of estrogen therapy, especially in combination with progestogen, may be associated with an increased risk of breast cancer. Regular breast examinations and mammograms are crucial for early detection.
4. Endometrial Cancer: For women who still have a uterus, unopposed estrogen therapy can promote endometrial hyperplasia and increase the risk of endometrial cancer. A progestogen is usually prescribed alongside estrogen for these patients.
5. Liver Conditions: Women with liver disease should use Elleste Duet with caution as they are metabolized in the liver. Liver function tests should be monitored periodically.
6. Hormone-Sensitive Conditions: Patients with a history of hormone-sensitive conditions (such as certain cancers, endometriosis, or uterine fibroids) should consult their healthcare provider before using Elleste Duet.
7. Hypertension: Estrogen can affect blood pressure. Regular monitoring of blood pressure is recommended, especially for individuals with a history of hypertension.
8. Drug Interactions: Elleste Duet may interact with certain medications, including those that induce liver enzymes (such as certain anticonvulsants and antimycotics). Inform your healthcare provider about all medications and supplements you are taking.
9. Psychological Effects: Hormonal therapy can influence mood and mental health. Patients should report any significant mood changes, depression, or unusual emotional symptoms to their healthcare provider.
10. Pregnancy and Breastfeeding: Elleste Duet should not be used during pregnancy or while breastfeeding due to potential risks to the fetus or infant.
11. Cholesterol Levels: Hormonal therapy can affect lipid profiles. Regular monitoring of lipid levels may be necessary, especially in women with a history of dyslipidemia.
12. Age Considerations: The risk of thromboembolic events may increase with age, particularly for women over 60. Use should be carefully considered in this population.
Get emergency medical help if you have signs of an allergic reaction to this medication. These include:
- Hives
- Dizziness
- Fast or pounding heartbeats
- Wheezing
- Difficult breathing
- Swelling of your face, lips, tongue, or throat.
It is important that you let us know which prescription, over-the-counter medicines and recreational drugs you are currently taking. You must also tell us about any other medical conditions that you currently have (or had in the past). This will help us ensure the prescribed medication is safe and appropriate for you to take.
For full information on warnings, medication interactions and contraindications, refer to the Patient Information Leaflet. Please read all packaging and the Patient Information Leaflet before taking any new medicine and inform our clinical team or your GP of medicines you are taking or intend to take.
