Evorel Conti patches are a form of hormone replacement therapy (HRT) designed specifically for women experiencing menopausal symptoms. Each patch contains a combination of estradiol and norethisterone, which are hormones that work together to alleviate symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness, while also providing endometrial protection.
Evorel Conti patches are transdermal systems applied to the skin and deliver a continuous release of hormones over a seven-day period. Patients typically change the patch once a week, thereby ensuring stable hormone levels in the bloodstream to improve symptom management.
Clinical studies have shown that Evorel Conti patches effectively reduce the frequency and severity of menopausal symptoms, leading to significant improvements in the quality of life for many women. By combining both estrogen and a progestogen (norethisterone), these patches not only address menopausal symptoms but also help protect the endometrium (lining of the uterus) from hyperplasia, which can occur with estrogen-only therapy.
The efficacy of Evorel Conti has been documented in various clinical trials, indicating that women using the patches experience a substantial reduction in bothersome symptoms such as hot flashes and night sweats, along with improvements in mood and general well-being.
Additionally, the patches can help protect against osteoporosis by maintaining bone density in postmenopausal women.
While Evorel Conti patches are generally well tolerated, some users may experience side effects, which can include skin reactions at the application site, headaches, breast tenderness, mood swings, and gastrointestinal disturbances. Serious but rare side effects may include an increased risk of thromboembolic events, such as deep vein thrombosis or pulmonary embolism, and it is
crucial for patients to discuss their individual risk factors with their healthcare provider.
Evorel Conti patches are contraindicated in women with certain conditions, such as a history of hormone-sensitive cancers, severe liver disease, or history of blood clots, which must be thoroughly assessed before starting therapy.
In summary, Evorel Conti patches provide an effective and convenient method for managing menopausal symptoms by delivering a combination of hormones in a consistent manner. Their use can significantly enhance quality of life, while regular monitoring by healthcare providers ensures safety and effectiveness in the management of menopause-related symptoms.
Evorel Conti patches are used for hormone replacement therapy (HRT) in women experiencing menopausal symptoms. Each patch contains a combination of estradiol and norethisterone and is typically applied to the skin once a week. The usual dosage involves applying one patch weekly, providing continuous hormone delivery over a 24-hour period.
To use Evorel Conti, apply the patch to a clean, dry, and hairless area of skin, such as the abdomen, buttocks, or upper arm. It is important to press the patch firmly onto the skin for about 30 seconds to ensure it adheres properly. The patch should be changed once a week, and the application site should be rotated to minimize skin irritation.
If you forget to change your Evorel Conti patch and it has been less than three days since it was due, apply a new patch as soon as you remember. However, if it has been more than three days, remove the old patch and apply a new one without applying an additional patch to make up for the missed dose.
For optimal therapeutic effectiveness, it is recommended to apply the patch at the same time each week. Regular follow-up appointments with your healthcare provider are essential to monitor symptom relief and manage any side effects. If you have questions about how to use Evorel Conti patches or concerns about missed doses, consult your healthcare provider for guidance.
Always use this medication exactly as your clinician has told you. Check with our clinical team or your GP or pharmacist if you are not sure.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Evorel Conti is a transdermal patch that combines both estradiol (an estrogen) and norethisterone (a progestogen). It is used in hormone replacement therapy (HRT) for women who have reached menopause and provides a continuous supply of hormones. While it can help alleviate menopausal symptoms, it may also cause side effects. Here’s a detailed overview of the potential side effects associated with Evorel Conti:
Common Side Effects
1. Skin Reactions Irritation, redness, or rash at the application site.
2. Breast Changes Tenderness, swelling, or changes in breast tissue.
3. Headaches Including migraines or tension-type headaches.
4. Nausea Gastrointestinal upset may occur.
5. Weight Changes Some women may experience weight gain or loss.
Less Common Side Effects
1. Mood Changes Anxiety, depression, or mood swings.
2. Gastrointestinal Issues Diarrhea or stomach cramps.
3. Fluid Retention Swelling in the ankles or hands.
Rare but Serious Side Effects
1. Thromboembolic Events Increased risk of blood clots, deep vein thrombosis, pulmonary embolism, and stroke.
2. Cardiovascular Issues Potential increase in blood pressure or heart attack risk.
3. Endometrial Hyperplasia Overgrowth of the uterine lining, which can lead to abnormal bleeding.
4. Liver Problems Changes in liver function or liver disease.
For full information on side effects and correct use, see the patient information leaflet. If any side effects concern you, or you are experiencing any of the side effects mentioned in the patient information leaflet whilst taking this medication, please contact our clinical team or speak to your GP.
Evorel patches, which deliver estradiol for hormone replacement therapy (HRT), come with specific cautions and warnings that patients should be aware of before and during use. Here’s a comprehensive overview:
1. Dosage and Administration: Adhere strictly to the prescribed regimen. Overuse or incorrect application of the patches can lead to elevated estradiol levels, resulting in potential side effects and complications.
2. Cardiovascular Risks: Evorel patches can increase the risk of thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Women with a history of cardiovascular disease, smoking, obesity, or prolonged immobility are at higher risk.
3. Breast Cancer Risk: Prolonged use of estrogen therapy, especially in combination with progestogen, may be associated with an increased risk of breast cancer. Regular breast examinations and mammograms are crucial for early detection.
4. Endometrial Cancer: For women who still have a uterus, unopposed estrogen therapy can promote endometrial hyperplasia and increase the risk of endometrial cancer. A progestogen is usually prescribed alongside estrogen for these patients.
5. Liver Conditions: Women with liver disease should use Evorel patches with caution as they are metabolized in the liver. Liver function tests should be monitored periodically.
6. Hormone-Sensitive Conditions: Patients with a history of hormone-sensitive conditions (such as certain cancers, endometriosis, or uterine fibroids) should consult their healthcare provider before using Evorel.
7. Hypertension: Estrogen can affect blood pressure. Regular monitoring of blood pressure is recommended, especially for individuals with a history of hypertension.
8. Drug Interactions: Evorel may interact with certain medications, including those that induce liver enzymes (such as certain anticonvulsants and antimycotics). Inform your healthcare provider about all medications and supplements you are taking.
9. Psychological Effects: Hormonal therapy can influence mood and mental health. Patients should report any significant mood changes, depression, or unusual emotional symptoms to their healthcare provider.
10. Pregnancy and Breastfeeding: Evorel patches should not be used during pregnancy or while breastfeeding due to potential risks to the fetus or infant.
11. Cholesterol Levels: Hormonal therapy can affect lipid profiles. Regular monitoring of lipid levels may be necessary, especially in women with a history of dyslipidemia.
12. Age Considerations: The risk of thromboembolic events may increase with age, particularly for women over 60. Use should be carefully considered in this population.
Get emergency medical help if you have signs of an allergic reaction to this medication. These include:
- Hives
- Dizziness
- Fast or pounding heartbeats
- Wheezing
- Difficult breathing
- Swelling of your face, lips, tongue, or throat.
It is important that you let us know which prescription, over-the-counter medicines and recreational drugs you are currently taking. You must also tell us about any other medical conditions that you currently have (or had in the past). This will help us ensure the prescribed medication is safe and appropriate for you to take.
For full information on warnings, medication interactions and contraindications, refer to the Patient Information Leaflet. Please read all packaging and the Patient Information Leaflet before taking any new medicine and inform our clinical team or your GP of medicines you are taking or intend to take.
