Oestrogel is a transdermal estrogen replacement therapy in the form of a cream, used primarily to alleviate symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness. It contains estradiol, a naturally occurring form of estrogen essential for maintaining various bodily functions in women.
Oestrogel is indicated for the treatment of menopausal symptoms in women who have not undergone a hysterectomy and is also used to prevent osteoporosis in postmenopausal women at risk. Patients typically apply the cream once daily to the skin, usually on the arms or inner thighs, using the dosing applicator provided to ensure accurate dosing. The typical starting dosage is often 1.25 g of Oestrogel, which contains 0.625 mg of estradiol.
Clinical studies have shown that Oestrogel effectively reduces the frequency and severity of hot flashes and night sweats, providing significant relief for many women and improving their quality of life. Additionally, it enhances vaginal health by alleviating dryness and discomfort, contributing to overall sexual well-being.
By replenishing estrogen levels, Oestrogel also plays a role in preventing postmenopausal bone loss, thereby reducing the risk of osteoporosis and related fractures. While generally well tolerated, potential side effects can include skin reactions at the application site, headaches, breast tenderness, and mood changes, as well as an increased risk of thromboembolic events.
Regular follow-up with a healthcare provider is essential to monitor the treatment response and adjust dosages as needed. However, Oestrogel is contraindicated in women with a history of certain conditions, such as hormone-sensitive cancers or deep vein thrombosis. Overall, Oestrogel is an effective option for managing menopausal symptoms and promoting health in postmenopausal women, with regular communication with healthcare providers ensuring its safe and effective use.
Oestrogel cream is used for hormone replacement therapy to treat menopausal symptoms in women. The usual recommended dosage is typically 1.25 g of Oestrogel applied to the skin once daily. This equates to one full dose of the dispensing pump or approximately one metered dose, which contains 0.625 mg of estradiol.
Oestrogel should be applied to clean, dry, and intact skin, usually on the thighs, buttocks, or arms, and it should not be applied to the breasts. It is important to allow the cream to dry completely before covering the application site with clothing to ensure proper absorption and effectiveness.
If you miss a dose of Oestrogel, apply it as soon as you remember on the same day. However, if it is nearly time for your next scheduled application, skip the missed dose and return to your regular dosing schedule; do not apply an extra dose to make up for the missed one.
For optimal results, consistency is key, so it’s advised to apply Oestrogel at the same time every
day. Regular follow-up appointments with your healthcare provider are essential to monitor treatment efficacy and adjust dosages as necessary.
Always use this medication exactly as your clinician has told you. Check with our clinical team or your GP or pharmacist if you are not sure.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Oestrogel is a transdermal gel that contains estradiol, a form of estrogen used in hormone replacement therapy (HRT). While it can be effective for alleviating menopausal symptoms, it may also have side effects. Here are some detailed side effects that can occur with Oestrogel:
Common Side Effects
1. Skin Reactions Irritation, redness, or rash at the application site.
2. Breast Changes Tenderness, swelling, or changes in breast tissue.
3. Abdominal Symptoms Nausea or bloating
Less Common Side Effects
1. Headaches Migraines or tension-type headaches.
2. Mood Changes Anxiety, depression, or mood swings.
3. Gastrointestinal Issues Diarrhea or stomach cramps.
Rare but Serious Side Effects
1. Thromboembolic Events Increased risk of blood clots, deep vein thrombosis, pulmonary embolism, and stroke.
2. Cardiovascular Issues Potential increase in blood pressure or heart attack risk.
3. Endometrial Hyperplasia Overgrowth of the uterine lining, which can lead to abnormal bleeding.
4. Liver Problems Changes in liver function or liver disease.
For full information on side effects and correct use, see the patient information leaflet. If any side effects concern you, or you are experiencing any of the side effects mentioned in the patient information leaflet whilst taking this medication, please contact our clinical team or speak to your GP.
1. Cardiovascular Risks: Long-term use of estrogen products, including Oestrogel, may elevate the risk of thromboembolic events such as deep vein thrombosis (DVT) and pulmonary embolism (PE), particularly in women with additional risk factors (e.g., smoking, obesity, or a history of cardiovascular disease).
2. Breast Cancer Risk: Some studies suggest that long-term use of estrogen HRT, particularly in combination with progestin, may be associated with an increased risk of breast cancer. Regular breast examinations and mammograms are recommended.
3. Endometrial Cancer Risk: For women with a uterus, unopposed estrogen therapy (estrogen without progesterone) can increase the risk of endometrial hyperplasia and cancer. Therefore, progestins are often used in conjunction with estrogen to mitigate this risk.
4. Liver Function: Women with liver disease should use Oestrogel with caution, as the liver metabolizes estrogens. Abnormal liver function tests should be closely monitored.
5. Hormone-Sensitive Conditions: Individuals with a history of hormone-sensitive conditions such as endometriosis, fibroids, or certain types of cancer (e.g., estrogen-dependent cancers) should consult their healthcare provider before using Oestrogel.
6. Blood Pressure: Estrogen can affect blood pressure. It is recommended to monitor blood pressure regularly while using Oestrogel, especially in individuals with a history of hypertension.
7. Drug Interactions: Oestrogel may interact with certain medications, such as those that affect liver enzymes (e.g., some anticonvulsants, antifungals, and antibiotics). Always inform your healthcare provider of all medications and supplements you are taking.
8. Psychological Effects: Hormonal changes can lead to mood swings or affect mental health. Patients should report any significant mood changes or symptoms of depression to their healthcare provider.
9. Pregnancy and Breastfeeding: Oestrogel should not be used during pregnancy or while breastfeeding, as the effects on fetal development and nursing infants are not fully understood.
Get emergency medical help if you have signs of an allergic reaction to this medication. These include:
- Hives
- Dizziness
- Fast or pounding heartbeats
- Wheezing
- Difficult breathing
- Swelling of your face, lips, tongue, or throat.
It is important that you let us know which prescription, over-the-counter medicines and recreational drugs you are currently taking. You must also tell us about any other medical conditions that you currently have (or had in the past). This will help us ensure the prescribed medication is safe and appropriate for you to take.
For full information on warnings, medication interactions and contraindications, refer to the Patient Information Leaflet. Please read all packaging and the Patient Information Leaflet before taking any new medicine and inform our clinical team or your GP of medicines you are taking or intend to take.
