Colecalciferol (vitamin D3) is a fat-soluble vitamin that plays a critical role in calcium and phosphate metabolism, which are vital for maintaining healthy bones and teeth. A dosage of 20,000 units is often recommended for treating moderate to severe vitamin D deficiency, especially in individuals with conditions that affect absorption, such as celiac disease or certain liver disorders.
Vitamin D promotes the absorption of calcium in the intestines and helps maintain adequate serum calcium and phosphate concentrations, which are essential for bone mineralization. It also plays a role in modulating cell growth, neuromuscular and immune function, and inflammatory responses.
This high-dose supplementation is indicated for those with documented deficiency based on blood tests showing low serum 25-hydroxyvitamin D levels, typically below 30 ng/mL. It may also be used preventively in high-risk populations, including the elderly, individuals with limited sun exposure, and those with darker skin.
Colecalciferol (vitamin D3) has proven effective in treating vitamin D deficiency by significantly elevating serum 25-hydroxyvitamin D levels. Its efficacy is particularly noted in promoting bone health, as it enhances calcium absorption, thereby reducing the risk of fractures, especially in older adults. In addition, adequate vitamin D levels contribute to improved immune function and may support overall well-being, including mood regulation.
Once vitamin D levels have been restored, a typical maintenance dose ranges from 600 to 2,000 units per day, although some individuals may require higher doses based on their specific health needs. Regular monitoring of serum vitamin D levels is essential to adjust the maintenance dose appropriately. Individual factors such as age, body weight, geographic location, and existing health conditions play a crucial role in determining the optimal maintenance dose.
According to the UK National Institute for Health and Care Excellence (NICE) guidelines, for individuals with significant vitamin D deficiency, an initial high-dose treatment of Colecalciferol (vitamin D3) may involve administering up to 20,000 units twice weekly for 7 weeks. After achieving sufficient serum levels, a maintenance dose is typically recommended, ranging from
800 to 2,000 units per day, tailored to individual needs.
Always use this medication exactly as your clinician has told you. Check with our clinical team or your GP or pharmacist if you are not sure.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Colecalciferol (vitamin D3) is generally considered safe when taken as directed, but like any medication or supplement, it can have side effects, especially when taken in excessive amounts. Here are the potential side effects associated with colecalciferol:
Common Side Effects
Nausea: Some individuals may experience mild nausea after starting vitamin D supplementation.
Vomiting: Occasionally, individuals may feel the need to vomit if they take too high a dose.
Constipation: Changes in bowel habits, including constipation, may occur.
Loss of Appetite: Some people might experience a decreased desire to eat.
Serious Side Effects
Hypercalcemia: Excessive vitamin D can lead to elevated levels of calcium in the blood (hypercalcemia), which can cause:
- Frequent urination
- Extreme thirst
- Nausea and vomiting
- Weakness and fatigue
- Confusion or altered mental status
- Kidney stones or damage
Hypercalciuria: Increased calcium levels in the urine may occur, potentially leading to kidney stone formation.
Pancreatitis: Though rare, elevated vitamin D levels can result in inflammation of the pancreas.
Cardiovascular Issues: Very high doses of vitamin D may contribute to cardiovascular problems due to increased calcium levels impacting heart function.
Other Considerations
Drug Interactions: Colecalciferol can interact with certain medications, including steroids, weight loss drugs, and seizure medications, potentially affecting their efficacy.
For full information on side effects and correct use, see the patient information leaflet. If any side effects concern you, or you are experiencing any of the side effects mentioned in the patient information leaflet whilst taking this medication, please contact our clinical team or speak to your GP.
When using colecalciferol (vitamin D3), it is important to be aware of the following cautions and warnings:
Cautions:
1. Kidney Disease: Individuals with kidney dysfunction or kidney stones should use caution, as vitamin D can raise calcium levels in the blood, potentially exacerbating kidney issues.
2. Hypercalcemia: Patients with a history of hypercalcemia (high blood calcium levels) should avoid taking high doses of vitamin D without medical supervision.
3. Sarcoidosis: Those with sarcoidosis or similar granulomatous diseases should be cautious, as these conditions can increase sensitivity to vitamin D and raise calcium levels.
4. Pregnancy and Breastfeeding: While vitamin D is essential during pregnancy and breastfeeding, it's crucial to follow healthcare provider guidelines regarding supplementation, as excessive intake can harm both mother and child.
5. Absorption Disorders: Individuals with conditions that affect fat absorption, such as cystic fibrosis, Crohn’s disease, or celiac disease, may require specific dosing adjustments.
6. Age Considerations: Elderly individuals are generally at higher risk for both deficiency and potential adverse effects from high doses, necessitating careful monitoring.
Warnings:
1. Avoid Excessive Doses: Taking vitamin D in amounts higher than what has been recommended can lead to toxicity. Dosages above 4,000 units per day are generally discouraged without medical guidance.
2. Medical Conditions: Those with certain medical conditions, such as primary hyperparathyroidism, should consult with healthcare providers before starting vitamin D supplementation.
3. Drug Interactions: Colecalciferol may interact with medications like thiazide diuretics, steroids, and anticonvulsants. Discuss any current medications with a healthcare professional to avoid adverse interactions.
4. Monitoring: Regular blood tests to check calcium and vitamin D levels are recommended for individuals on high doses or those with conditions that may affect absorption or metabolism.
5. Signs of Toxicity: Be vigilant for symptoms of vitamin D toxicity, such as nausea, vomiting, weakness, and confusion, and seek medical attention if these occur.
Get emergency medical help if you have signs of an allergic reaction to this medication. These include:
- Hives
- Dizziness
- Fast or pounding heartbeats
- Wheezing
- Difficult breathing
- Swelling of your face, lips, tongue, or throat.
It is important that you let us know which prescription, over-the-counter medicines and recreational drugs you are currently taking. You must also tell us about any other medical conditions that you currently have (or had in the past). This will help us ensure the prescribed medication is safe and appropriate for you to take.
For full information on warnings, medication interactions and contraindications, refer to the Patient Information Leaflet. Please read all packaging and the Patient Information Leaflet before taking any new medicine and inform our clinical team or your GP of medicines you are taking or intend to take.
