Evorel patches are a transdermal hormone replacement therapy (HRT) specifically designed for the treatment of menopausal symptoms in women. Each patch contains estradiol, a form of estrogen that helps alleviate symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness.
Evorel patches are applied directly to the skin and deliver a consistent dose of estradiol over a 24-hour period. The patches are typically changed twice a week, providing a convenient and
non-invasive method of hormone delivery. This allows for stable hormone levels in the bloodstream, which can help improve symptom management.
Clinical studies have demonstrated that Evorel patches effectively reduce the frequency and severity of menopausal symptoms. Many women report significant improvement in quality of life, as the patches help alleviate bothersome symptoms that can interfere with daily activities and overall well-being. Additionally, by restoring estrogen levels, these patches also provide benefits for bone health, helping to reduce the risk of osteoporosis in postmenopausal women.
Evorel patches are usually well tolerated, but some patients may experience side effects, including skin reactions at the application site, headaches, breast tenderness, and mood changes. Regular monitoring by healthcare providers is essential to assess treatment effectiveness and manage any potential side effects.
Evorel patches are contraindicated in women with certain conditions, such as a history of hormone-sensitive cancers, untreated hypertension, or a history of thromboembolic disorders. Therefore, a thorough medical history should be evaluated before initiation of therapy.
Overall, Evorel patches provide an effective, convenient, and reliable option for managing menopausal symptoms, significantly improving the quality of life for many women during and after the menopausal transition, while regular follow-up visits ensure optimal treatment outcomes and safety.
Evorel patches are used for hormone replacement therapy to treat menopausal symptoms in women. Each patch is typically applied to the skin once a week for continuous hormone delivery. The usual starting dose is one patch containing 50 micrograms of estradiol, although this may be adjusted according to individual symptoms and treatment response, with options for patches of varying estradiol strengths available.
To apply an Evorel patch, choose a clean, dry, and hairless area of skin, such as the abdomen, buttocks, or upper arm. Press the patch firmly onto the skin for about 30 seconds to ensure good adhesion, and allow it to remain in place for a full week. The patch should be changed weekly, and a new patch should be applied to a different site to avoid skin irritation.
If you forget to change your Evorel patch and it has been less than 3 days since it was supposed to be changed, replace it with a new patch as soon as you remember. However, if it has been more than 3 days, remove the old patch and apply a new one, but do not double the patches to make up for the missed dose.
For optimal results, it is recommended to apply the patch at the same time each week, and regular follow-up appointments with your healthcare provider are important to assess treatment efficacy and manage any potential side effects. If you have any questions about how to use Evorel patches or concerns regarding missed doses, consult your healthcare provider for personalized guidance.
Always use this medication exactly as your clinician has told you. Check with our clinical team or your GP or pharmacist if you are not sure.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Evorel patches are transdermal patches that contain estradiol, used in hormone replacement therapy (HRT) to relieve symptoms of menopause. Like any medication, they can cause side
effects, which may vary in severity. Here's a detailed overview of the potential side effects associated with Evorel patches:
Common Side Effects
1. Skin Reactions Irritation, redness, or rash at the application site.
2. Breast Changes Tenderness, swelling, or changes in breast tissue.
3. Headaches Including migraines or tension-type headaches.
4. Nausea Gastrointestinal upset may occur.
5. Weight Changes Some women may experience weight gain or loss.
Less Common Side Effects
1. Mood Changes Anxiety, depression, or mood swings.
2. Gastrointestinal Issues Diarrhea or stomach cramps.
3. Fluid Retention Swelling in the ankles or hands.
Rare but Serious Side Effects
1. Thromboembolic Events Increased risk of blood clots, deep vein thrombosis, pulmonary embolism, and stroke.
2. Cardiovascular Issues Potential increase in blood pressure or heart attack risk.
3. Endometrial Hyperplasia Overgrowth of the uterine lining, which can lead to abnormal bleeding.
4. Liver Problems Changes in liver function or liver disease.
For full information on side effects and correct use, see the patient information leaflet. If any side effects concern you, or you are experiencing any of the side effects mentioned in the patient information leaflet whilst taking this medication, please contact our clinical team or speak to your GP.
Evorel patches, which deliver estradiol for hormone replacement therapy (HRT), come with specific cautions and warnings that patients should be aware of before and during use. Here’s a comprehensive overview:
1. Dosage and Administration: Adhere strictly to the prescribed regimen. Overuse or incorrect application of the patches can lead to elevated estradiol levels, resulting in potential side effects and complications.
2. Cardiovascular Risks: Evorel patches can increase the risk of thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Women with a history of cardiovascular disease, smoking, obesity, or prolonged immobility are at higher risk.
3. Breast Cancer Risk: Prolonged use of estrogen therapy, especially in combination with progestogen, may be associated with an increased risk of breast cancer. Regular breast examinations and mammograms are crucial for early detection.
4. Endometrial Cancer: For women who still have a uterus, unopposed estrogen therapy can promote endometrial hyperplasia and increase the risk of endometrial cancer. A progestogen is usually prescribed alongside estrogen for these patients.
5. Liver Conditions: Women with liver disease should use Evorel patches with caution as they are metabolized in the liver. Liver function tests should be monitored periodically.
6. Hormone-Sensitive Conditions: Patients with a history of hormone-sensitive conditions (such as certain cancers, endometriosis, or uterine fibroids) should consult their healthcare provider before using Evorel.
7. Hypertension: Estrogen can affect blood pressure. Regular monitoring of blood pressure is recommended, especially for individuals with a history of hypertension.
8. Drug Interactions: Evorel may interact with certain medications, including those that induce liver enzymes (such as certain anticonvulsants and antimycotics). Inform your healthcare provider about all medications and supplements you are taking.
9. Psychological Effects: Hormonal therapy can influence mood and mental health. Patients should report any significant mood changes, depression, or unusual emotional symptoms to their healthcare provider.
10. Pregnancy and Breastfeeding: Evorel patches should not be used during pregnancy or while breastfeeding due to potential risks to the fetus or infant.
11. Cholesterol Levels: Hormonal therapy can affect lipid profiles. Regular monitoring of lipid levels may be necessary, especially in women with a history of dyslipidemia.
12. Age Considerations: The risk of thromboembolic events may increase with age, particularly for women over 60. Use should be carefully considered in this population.
Get emergency medical help if you have signs of an allergic reaction to this medication. These include:
- Hives
- Dizziness
- Fast or pounding heartbeats
- Wheezing
- Difficult breathing
- Swelling of your face, lips, tongue, or throat.
It is important that you let us know which prescription, over-the-counter medicines and recreational drugs you are currently taking. You must also tell us about any other medical conditions that you currently have (or had in the past). This will help us ensure the prescribed medication is safe and appropriate for you to take.
For full information on warnings, medication interactions and contraindications, refer to the Patient Information Leaflet. Please read all packaging and the Patient Information Leaflet before taking any new medicine and inform our clinical team or your GP of medicines you are taking or intend to take.
